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Open this dialog box by clicking the dialog box launcher in the Paragraph group on the Home tab The settings are as follows: Before Text: This is a general left indent setting It sets both the hanging indent marker and the left indent marker Special: This controls what happens to the rst line The choices are Hanging, First Line, or None To indent the rst line to the left of the others, choose Hanging If you want the rst line to the right of the others, choose First Line..

detected after 24 h An in vivo study of the long-circulating phage and the wild-type coliphages was conducted using a mouse model Four groups of mice were injected with 108 cfu of E coli CRM1 The rst group was a control, with no phage treatment Within 5 h, these mice showed symptoms of illness including ruf ed fur, lethargy, and hunchback posture After 24 h, they were moribund, and they died within 48 h Three groups of phage were treated with 1010 PFU of phage All of the mice that were treated with phage survived However, those treated with W60 (group 2) had severe illness before nally recovering, while those treated with Argol (group 3) and Argo2 (group 4) exhibited only minor signs of illness before complete recovery.

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where the last term is nonnegative definite for any K since R, 1 0. Now the criterion in (3.4) is related to J ( K ) via E%*%= Tr[J(K)] so that, from (3.19),

Analysis of the capsid proteins of the wild-type (W60) and mutant phages (Argo1 and 2) revealed an alkaline shift in the 38-kDa major viral protein in Argol compared with W60 The same electrophoretic protein shift was observed in Argo2 The protein was subsequently identi ed as the major capsid head protein E Sequence analysis of the protein E gene in Argol and Argo2 revealed a G A transition mutation at nt 6606 in both phages This transition mutation resulted in the substitution of the basic amino acid lysine for the acidic amino acid glutamic acid at position 158 of the capsid E protein in both Argo strains Argo2 protein pro les displayed the presence of an additional altered protein, which also had an alkaline shift Analysis and characterization showed that the mutation was located within the major capsid head protein D of .

or (8.92) For our analytical discussion of one-dimensional diffusion, (8.79) and (8.82) are manifestly equivalent and, by comparing (8.90) with (8.92) after differentiation, we further expect DGKand DE to be equivalent; we hence focus on the comparison of DGKand DHE.For the further arguments, the stochastic integral expression

Based on their results, the authors concluded that the use of toxinfree, bacteria-speci c phage strains, combined with the serial-passage technique, may provide a viable method for developing phage into therapeutically effective antibacterial agents (Merril et al 1996) Alternative approaches have been employed in an attempt to decrease immunogenicity of phages and decrease clearance by the RES Kim et al (2008) chemically modi ed phages by conjugation of the polymer monomethoxy-polyethylene glycol (mPEG) to phage proteins This polymer is non-immunogenic, so the rationale for the study was based on the fact that conjugating mPEG to the phages would mask them, thereby increasing their blood circulation time Two myophages (Felix-O1 [infects Salmonella spp] and A511 [infects Listeria spp]) were used in the experiments Loss of phage infectivity following PEGylation was found to be proportional to the degree of modi cation, and could be controlled by adjusting the PEG concentration.

encoded in about 300 domain-independent rules, somewhat similar in principle to Jennings's teamwork rules, as shown above. However, the cooperation rules of Steam are far more complex, allowing for sophisticated hierarchical team structures. The Steam framework was used in a number of application domains, including military mission simulations, as well as the RoboCup simulated robotic soccer domain.

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When injected into naive mice, PEGylated phages showed a strong increase in circulation half-life, whereas challenge of immunized mice did not reveal a signi cant difference The results of the study suggest that the prolonged half-life is due to decreased susceptibility to innate.

I . R.A. Adams, J.J.F. Fournier: Sobolev Spuce.~, edition. Academic PressElsevier, Amster2nd dam, 2003. 2. A. Ahagon, K. Fujiwara, T. Nakata: Comparison of various kinds of edge elements for electromagnetic field analysis. IEEE Trans. Magn. 32, 898-901, 1996.

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